Hemophilia

Clinical expertise and laboratory innovation.

Versiti Diagnostic Labs is proud to offer one of the largest diagnostic menus to accurately and confidently diagnose hemophilia.

A bleeding disorder characterized by low levels of clotting factor proteins, the correct diagnosis of hemophilia is essential to providing effective treatment. 

Hemophilia is an X-linked inherited bleeding disorder caused by mutation of the F8 or F9 gene Genetic analysis is useful for identification of the underlying genetic defect in males with severe, moderate or mild hemophilia and for determination of carrier status in the female individuals within their families.

Two algorithms for targeted diagnosis

Versiti Blood Center of Wisconsin provides a comprehensive menu of diagnostic tests for persons with hemophilia. This menu includes factor activity tests, factor inhibitor testing and comprehensive genetic testing.

1091

Factor IX Activity

This assay measures activity of factor IX.

1093

Factor IX Activity - Hepzyme Treated

This assay measures activity of factor IX, with addition of hepzyme to neutralize the influence of heparin.

1095

Factor IX Inhibitor Profile

This order set includes both Factor IX Activity and Factor IX Inhibitor.

1094

Factor IX Inhibitor Profile - Hepzyme Treated

This order set includes both Factor IX Activity and Factor IX Inhibitor, both including the addition of hepzyme to neutralize the influence of heparin.

1401

Factor VIII (F8) Intron 1 Inversion Analysis

F8 intron 1 Inversion Analysis is appropriate for individuals with a family history of severe hemophilia A known to be caused by this pathogenic variant.

1400

Factor VIII (F8) Intron 22 Inversion Analysis

F8 intron 22 Inversion Analysis is appropriate for individuals with a family history of severe hemophilia A known to be caused by this pathogenic variant.

1402

Factor VIII (F8) Inversion Analysis

Factor 8 (F8) inversion analysis evaluates both the intron 1 and intron 22 inversions, and is recommended only for males with severe hemophilia A, or females who have a family history of severe unknown type of hemophilia A, or females with low factor VIII levels who have no known family history of hemophilia. This assay is included in the Factor VIII (F8) severe HA Analysis-Reflex test. F8 variants other than inversions are not detected by this assay.

1403

Factor VIII (F8) Severe HA Analysis-Reflex

This testing is recommended for the detection of germline variants associated with severe Hemophilia A . Testing begins with F8 inversion Analysis; if this analysis is negative, F8 Sequence Analysis is performed at an additional charge. Refer to F8 Inversion Analysis and F8 Sequence Analysis for test information.

1135

Factor VIII Activity - Chromogenic

The chromogenic factor VIII activity assay uses bovine reagents, is insensitive to emicizumab and lupus anticoagulant, and is adversely affected by the presence of direct factor X inhibitors or high concentrations of heparin.

1081

Factor VIII Activity - Clot based

This test measures the activity of factor VIII to aid in diagnosis of hemophilia A, acquired factor VIII deficiency, or as part of diagnostic workup for von Willebrand disease (VWD).

1315

Factor VIII Activity - Concentrate

This test is used to determine the level of the coagulation protein Factor VIII in a vial of factor concentrate.

1310

Factor VIII Activity - Cryoprecipitate

This test is used to determine the level of the coagulation protein Factor VIII in a unit or pool of cryoprecipitate. Contact laboratory for additional information.

1342

Factor VIII Activity - Plasma QC

This test is used to determine the level of the coagulation protein Factor VIII in a unit or Fresh Frozen Plasma or Recovered Plasma. Contact laboratory for additional information.

1136

Factor VIII Activity Hepzyme Treated - Chromogenic

The chromogenic factor VIII activity assay uses bovine reagents, is insensitive to emicizumab and lupus anticoagulant, and is adversely affected by the presence of direct factor X inhibitors or very high concentrations of heparin (greater than 2 U/mL). The addition of hepzyme in this assay will neutralize the influence of heparin.

1082

Factor VIII Activity Hepzyme Treated - Clot based

This assay measures activity of factor VIII, with addition of hepzyme to neutralize the influence of heparin.

1137

Factor VIII Inhibitor

The chromogenic factor VIII inhibitor assay uses bovine reagents, is insensitive to emicizumab and lupus anticoagulant, and is adversely affected by the presence of direct factor X inhibitors or high concentrations of heparin.

1138

Factor VIII Inhibitor - Hepzyme Treated

The chromogenic factor VIII inhibitor assay uses bovine reagents, is insensitive to emicizumab and lupus anticoagulant, and is adversely affected by the presence of direct factor X inhibitors or very high concentrations of heparin (greater than 2 U/mL). The addition of hepzyme in this assay will neutralize the influence of heparin.

1086

Porcine Factor VIII Inhibitor Profile

This order set includes both Factor VIII Activity-Clot based and Porcine Factor VIII Inhibitor.

1084

Porcine Factor VIII Inhibitor Profile - Hepzyme Treated

This order set includes both Factor VIII Activity-Clot based and Porcine Factor VIII Inhibitor, with addition of hepzyme to neautralize the influence of heparin

 
Diagnostic Laboratories
Diagnostic laboratory services including HLA testing, donor testing, immunohematology reference lab testing, hematology testing and more.
 
Hematology Testing
Versiti provides von Willebrand factor tests, aHUS diagnosis, hemophilia lab tests and other laboratory diagnosis of bleeding and clotting disorders.
 
Requisitions
Access requisitions for Versiti Diagnostic Laboratories.