Hematology Genetics Testing Lab
Versiti’s Hematology Genetics lab provides integrated genetic lab services that include functional diagnostics and disease-focused genetic analysis to guide superior care for patients with hematologic disorders.
Versiti’s Hematology Genetics portfolio has been designed to ensure:
- Thoughtful gene-disease curation, gene selection and panel design
- Utilization management and laboratory stewardship to support you in receiving the most tailored, cost-effective option for each unique patient
- Clinically actionable results that explain molecular findings specific to each patient’s case
- 4825 – Comprehensive Bleeding Disorder Panel
- 4830 – Comprehensive Platelet Disorder Panel
- 4815 – Coagulation Disorder Panel
- 4845 – Congenital Neutropenia Panel
- 4850 – Custom Blood Disorder Panel
- 4835 – Platelet Function Disorder Panel
- 4820 – Thrombosis Panel
- 4840 – Inherited Thrombocytopenia Panel
- 4855 – Single Gene Sequence Analysis
- 4970 – Targeted Familial Variant Analysis
- 4860 – Fibrinolytic Disorder Panel
- 4865 – Autosomal Dominant Thrombocytopenia Panel
- 1200 – aHUS/DDD Genetic Evaluation
- 4880 – Bernard-Soulier Syndrome Panel
- 4885 – Fibrinogen Disorders Panel
- 4870 – Glanzmann Thrombasthenia Panel
- 4875 – Hermansky-Pudlak Syndrome Panel
Disease-focused for high-quality analysis
With Versiti, you can feel confident knowing that each panel is specifically designed for hematology diagnosis, with careful gene-by-gene selection for clinical validity and utility, with comprehensive coverage of relevant regions. By comparison, panels built upon an exome or genome platform to analyze data across the entire set of human genes typically scale back data analysis to cover only designated genes. In this approach, breadth is offered at the expense of depth, resulting in gaps in coverage of potentially relevant genes.
Our NGS panels are custom-built and designed to include every clinically relevant part of each gene expertly selected for inclusion. Supplemental Sanger sequencing is included in our panel design to optimize reliable and accurate detection of relevant variants. This approach to panel design maximizes diagnostic utility and minimizes the risk of off-target results or incidental findings more likely to be identified by a broader testing platform designed for a less specific purpose.
Large deletions and duplications, also referred to as copy number variation (CNV), are a known cause of genetic disorders, but can escape detection by standard sequence analysis. Depending on the gene of interest, deletiosn and duplications have been shown to be responsible for approximately 10% of genetic disease. Array comparative genomic hybridization (aCGH) has proven to be a highly sensitive and accurate tool in detection of these deletions and duplications. High-resolution aCGH complements DNA sequencing and provides comprehensive mutation analysis.
Specifically designed panels:
- Clarification and/or confirmation of diagnosis in a patient with clinical and laboratory findings of a hematologic disorder when patient’s history suggests multiple disorders
- Identification of carriers with family history of unspecified bleeding disorders to provide accurate reproductive risk assessment and genetic counseling
Sample report available upon request.
Advancing precision medicine through collaborative laboratory stewardship
An integral component of Versiti’s hematology genetics services is an active laboratory stewardship and utilization guidance program to improve the value of laboratory services for providers and patients. Our multidisciplinary team reviews 100% of genetic testing requisitions, resulting in modifications for optimized testing or cost savings in 8.7% of all cases*. Our laboratory genetic counselors are always available for clinical consultation, and our multidisciplinary team of practicing hematologists, laboratory geneticists and genetic counselors actively reviews patient clinical history, contacts the provider with clarifying questions as necessary, and works with clinicians to optimize orders as appropriate.
Our primary goals through our services are to:
- Reduce unnecessary testing and help ensure the most appropriate genetic test is ordered
- Avoid excess financial liability for providers and their patients
Learn more about Lab Stewardship.
Membership in PLUGS®
We are proud to be a member and sponsor of PLUGS (Patient-centered Laboratory Utilization Guidance Services), in its national mission to increase the value of testing to patients through advocacy of laboratory test stewardship.
"The proper ordering and interpretation of advanced next generation sequencing panels requires a client-focused utilization management (UM) effort. [Versiti] is a leader in combining the most advanced specialty testing with superb UM support."
Mike Astion, MD, PhD
Medical Director, Department of Laboratories
Senior Vice President, PLUGS
Seattle Children’s Hospital
*Based on prior data analysis