Versiti - Sarah Mueller, MD, PhD | Versiti Diagnostic Laboratories

Sarah Mueller, MD, PhD

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Sarah Mueller, MD, PhD

Medical Director, Diagnostic Hematology


Education and Training

Clinical Fellow, Molecular Genetic Pathology
Brigham and Women's Hospital

Graduate Assistant, Pathology
Massachusetts General Hospital

Resident, Clinical Pathology, Chief Resident, Clinical Pathology
Massachusetts General Hospital

Chief Resident, Clinical Pathology
Massachusetts General Hospital

Duke University School of Medicine

BA in Chemistry
Washington University in St. Louis College of Arts and Sciences

Specialty Boards and Certifications

Wisconsin Medical License #82271-20 | Expiration 10/31/2023

Massachusetts Medical License #289256 | Expiration 11/27/2024

Certification in Clinical Pathology, American Board of Pathology

Contact Information

Note: formerly known as Frazier, SB

Mueller SB, Pikman Y, Tasian SK, Silverman LB, Harris MH, Tsai HK. ETV6 fusions from insertions of exons 3-5 in pediatric hematologic malignancies. Haematologica. 2023 Jun 29. doi: 10.3324/haematol.2022.282498. Epub ahead of print. PMID: 37381775.

Kahn SA, Leonard MM, Westra SJ, Hausmann JS, Mueller SB. Case 3-2023: A 16-Year-Old Girl with Abdominal Pain and Bloody Diarrhea. N Engl J Med. 2023 Jan 26;388(4):358-368. PMID: 36720137.

Mueller SB, Dal Cin P, Le LP, Dias-Santagata D, Lennerz JK, Iafrate AJ, Marble HD, Brunner AM, Weinstock MJ, Luskin MR, DeAngelo DJ, Stone RM, Nardi V. t(4;12)(q12;p13) ETV6-rearranged AML without eosinophilia does not involve PDGFRA: relevance for imatinib-insensitivity. Blood Adv. 2022 Jan 8;6(3):818-827. PMID: 34587239.

Fourman LT, Mueller SB, Boutin A, Zheng I, Pan CS, Gerard ME, Stanley TL, Roberts DJ. Placental Vascular Abnormalities in Association with Prenatal and Long-term Health Characteristics Among HIV-Exposed Uninfected Adolescents and Young Adults. J Acquir Immune Defic Syndr. 2021 May 20. PMID: 34034303.

Detweiler CJ, Mueller SB, Sung AD, Saullo JL, Prasad VK, Cardona DM. Brincidofovir (CMX001) Toxicity Associated with Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity from GVHD. J Pediatr Hematol Oncol. 2018. Aug;40(6):e364-e368. PMCID: PMC6059994

McClung JM, McCord TJ, Ryan TE, Schmidt CA, Green TD, Southerland KW, Reinardy JL, Mueller SB, Venkatraman TN, Lascola CD, Keum S, Marchuk DA, Spangenburg EE, Dokun AO, Annex BH, Kontos CD. A BAG3 Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. Circulation. 2017. Jul 18;136(3):281-296. PCMID: PMC5537727

Mueller SB, Kontos CD. Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling. J Clin Invest. 2016 Sep 1;126(9):3188-91. PMCID: PMC5004958

Reinardy JL, Corey DM, Golzio C, Mueller SB, Katsanis N, Kontos CD. Phosphorylation of threonine 794 on Tie1 by Rac1/PAK1 reveals a novel angiogenesis regulatory pathway. PLoS ONE. 2015. Oct 5;(10):e0139614. PMCID: PMC4593579

McClung JM, Reinardy JL, Mueller SB, McCord TJ, Kontos CD, Brown DA, Hussain SNA, Schmidt CA, Ryan TE, Green TD. Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment. Front Physiol. 2015 May; 6:161. PMCID: PMC4436568

Mueller SB, Kontos CD. Gene therapy for the prevention of vein graft disease. Chapter in Translating Gene Therapy to the Clinic. Editors: Jeffrey Laurence and Michael Franklin. Elsevier 2015. ISBN: 978-0-12-800563-7

Southerland KW*, Frazier SB*, Bowles DE, Milano CA, Kontos CD. Gene Therapy for the prevention of vein graft disease. Transl Res. 2013 Apr; 161(4):321-38. PMID: 23274305. *Equal contribution first authors.

Pan J, Qian Y, Zhou X, Pazandak A, Frazier SB, Weiser P, Lu H, Zhang L. Oversulfated chondroitin sulfate is not the sole contaminant in heparin. Nat Biotechnol. 2010 Mar; 28(3):203-7. PMID: 20212477

Pan J, Qian Y, Zhou X, Pazandak A, Frazier SB, Weiser P, Lu H, Zhang L. Identification of Chemically Sulfated/desulfated Glycosaminoglycans in Contaminated Heparins and Development of a Simple Assay for the Detection of Most Contaminants in Heparin. Glycobiol Insights. 2010 Feb 2; 2010(2): 1-12. PMCID: PMC2909132

Frazier SB, Roodhouse KA, Hourcade DE, Zhang L. The Quantification of Glycosaminoglycans: A Comparison of HPLC, Carbazole, and Alcian Blue Methods. Open Glycosci. 2008 Jan1; 1:31-39. PMCID: PMC2904615

National/International Platform Presentations

Note: poster presentations and local/regional platform presentations not included

Mueller SB, Dal Cin P, Le LP, Dias-Santagata D, Lennerz JK, Iafrate AJ, Marble HD, Brunner AM, Weinstock MJ, Luskin MR, DeAngelo DJ, Stone RM, Nardi V. ETV6-PDGFRA fusions detected by FISH in acute myeloid leukemia with translocation t(4;12)(q12;p13) are false-positive. Cancer Genomics Consortium Annual Meeting. 2021 Aug 2. Virtual.

Mueller SB, McCord TJ, Padgett M, Kontos CD. The scaffolding protein Caskin2 regulates vascular homeostasis downstream of Angiopoietin/Tie receptor signaling. International Vascular Biology Meeting. 2018 Jun 4. Helsinki, Finland.

Mueller SB, Gurley SB, Kontos CD. The undescribed protein Caskin2 is a novel regulator of eNOS phosphorylation and systemic blood pressure. Hypertension. 2015 Sep 1; 66:A066. Washington DC, USA.

Mueller SB, Arora A, Mattocks N, Gurley SB, Kontos CD. Caskin2 is a novel regulator of endothelial cell quiescence. ATVB. 2014 May 1; 34:A14. Toronto, ON, Canada.

Invited Presentations

Mueller SB, Nardi V. Targeted RNA sequencing of t(4;12)(q12;p13) AML reveals multiple cases of false-positive ETV6::PDGFRA FISH. New England Society of Pathologists. 2023 Jan 24. Boston, MA

Diagnostic Laboratories
Diagnostic laboratory services including HLA testing, donor testing, immunohematology reference lab testing, hematology testing and more.
Hematology Genetics Testing
The Hematology Genetic Testing Lab provides specialized hematology genetics custom testing panels, single gene testing and more.
Human Leukocyte Antigen (HLA) Typing
Versiti Diagnostic Labs’ Histocompatibility Lab provides human leukocyte antigen (HLA) typing for solid organ transplant and HCT patients.
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