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Human Platelet Antigen (HPA) Database

The database provides a centralized repository for discovered and known human platelet antigens.

Human Platelet Antigen (HPA) Database

This database serves as the principal site for cataloging the current list of human platelet allo-antigens (HPA). To submit data and obtain confirmation and numbering of newly discovered HPA by the International Platelet Immunology Nomenclature Committee of the International Society of Blood Transfusion (ISBT), please use the official forms and instructions on this page.

Alloantibodies against HPA are the cause of several immune platelet disorders, including fetal and neonatal alloimmune thrombocytopenia (FNAIT) and platelet transfusion refractoriness (PTR). Detection and identification of HPA alloantibodies is critical in making a proper diagnosis and for ensuring appropriate patient care.

Submit New Antigen

Please review database for all currently know Human Platelet Antigens. Submit any newly discovered antigens via the form below and they will be reviewed.

New Submission Form

HPA Gene Database

Use the database to search for any of the current 35 recognized human platelet antigens.

System	Antigen	Original names	Glycoprotein / SNP	CD	Reference
HPA-1	HPA-1a HPA-1b	Zw^a, Pl^A1 Zw^b,PI^A2	GPIIIa /L33P^†	CD61	van Loghem et al, Vox Sang (1959) Shulman et al, J Clin Invest (1961) van der Weerdt et al, Vox Sang (1963)
HPA-2	HPA-2a HPA-2b	Ko^a, Ko^b	GPIbα / T145M	CD42b	van der Weerdt et al, (1969) van der Weerdt, (1965)
HPA-3	HPA-3a HPA-3b	Bak^a, Lek^a Bak^b	GPIIb / I8435	CD41	von dem Borne et al, Vox Sang (1980) Kickler et al, Blood (1988)
HPA-4	HPA-4a HPA-4b	Yuk^b, Pen^a Yuk^a, Pen^b	GPIIIa / R143Q	CD61	Friedman et al, Blood (1985) Shibata et al, Vox Sang (1986) Shibata et al, Vox Sang (1986)
HPA-5	HPA-5a HPA-5b	Br^b, Zav^b Br^a, Zav^a, Hc^a	GPIa / E505K	CD49b	Kiefel et al, Vox Sang (1988) Kiefel et al, Blood (1989) Santoso et al, Br J Haematol (1989)
	HPA-6b	Ca^a, Tu^a	GPIIIa / R489Q	CD61	Kekomäki et al, Br J Haematol (1993) McFarland et al, Blood (1993)
	HPA-7b	Mo^a	GPIIIa / P407A	CD61	Kuijpers et al, Blood (1993)
	HPA-8b	Sr^a	GPIIIa / R636C	CD61	Kroll et al, Blood (1990)
	HPA-9b	Max^a	GPIIb / V837M	CD41	Noris et al, Blood (1995)
	HPA-10b	La^a	GPIIIa / R62Q	CD61	Peyruchaud et al, Blood (1997)
	HPA-11b	Gro^a	GPIIIa / R633H	CD61	Simsek et al, Blood (1994)
	HPA-12b	Iy^a	GPIbβ / G15E	CD42c	Kiefel et al, Vox Sang (1995)
	HPA-13b	Sit^a	GPIIIa / K611del	CD49b	Santoso et al, Blood (1999)
	HPA-14b	Oe^a	GPIIIa / K611del	CD61	Santoso et al, Blood (2002)
HPA-15	HPA-15a HPA-15b	Gov^b Gov^a	CD109 / S682Y	CD109	Kelton et al, Blood (1990) Smith et al, Blood (1995)
	HPA-16b	Duv^a	GPIIIa / T140I	CD61	Jallu et al, Blood (2002)
	HPA-17b	Va^a	GPIIIa / T195M	CD61	Kekomäki et al, Trasfus Med (1992)
	HPA-18b	Cab^a	GPIa/ Q716H	CD49b	Bertrand et al, Transfusion (2009)
	HPA-19b	Sta	GPIIIa / K137Q	CD61	Peterson et al, Transfusion (2010)
	HPA-20b	Kno	GPIIb/ T619M	CD41	Peterson et al, Transfusion (2010)
	HPA-21b	Nos	GPIIIa/ E628K	CD61	Peterson et al, Transfusion (2010)
	HPA-22b	Sey	GPIIb/ K164T	CD41	Peterson et al, Transfusion (2012)
	HPA-23b	Hug	GPIIIa/ R622W	CD61	Peterson et al, Transfusion (2012)
	HPA-24b	Cab2^a+	GPIIb/ S472N	CD41	Jallu et al, Transfusion (2011)
	HPA-25b	Swi^a	GPIa/ T1087M	CD49b	Kroll et al, Transfusion (2011)
	HPA-26b	Sec^a	GPIIIa / K580N	CD61	Sachs et al, Thromb Haemost (2012)
	HPA-27b	Cab^3a+	GPIIb / L841M	CD41	Jallu et al, Transfusion (2013)
	HPA-28b	War	GPIIb / V740L	CD41	Poles et al, Transfusion (2013)
	HPA-29b	Kha^b	GPIIIa / T33M†	CD61	Sullivan et al, Transfusion (2015)
	HPA-30b	Lab^a	GPIIb / Q806H	CD41	Wihadmadyatami et al, Transfusion (2015)
	HPA-31b	Cab4^b+	GPIX / P123L	CD42a	Jallu et al, J Thromb Haemost (2017)
	HPA-32b	Dom^b	GPIIIa / N174S	CD61	Sullivan et al, Transfusion (2017)
	HPA-33b	Bl^a	GPIIIa / D458G	CD61	Poles et al, Transfusion (2019)
	HPA-34b	Bzh^a	GPIIIa / R91W	CD61	Bertrand et al, Transfusion (2019)
	HPA-35b	Efs^a	GPIIIa / R479H	CD61	Bertrand et al, Transfusion (2019)

Human Platelet Antigen (HPA) Database

Human Platelet Antigen (HPA) Database

Submit New Antigen

HPA Gene Database

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Brian Curtis, PhD, D(ABMLI), MT(ASCP) SBB

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