Myeloproliferative Neoplasms

Diagnosing Myeloproliferative Neoplasm (MPN) disorders presents unique challenges. Versiti can simplify and streamline the diagnostic process for you. Our experienced Diagnostic Laboratories team, and our desire to provide you with industry-leading service, allow us to provide you with much more than a test result.

Myeloproliferative neoplasms (MPNs) are a group of diseases that affect blood cell formation. They are characterized by the proliferation of one or more myeloid cell lines in bone marrow, and increased numbers of mature and immature cells in the peripheral blood. Classic myeloproliferative disorders include:

  • Polycythemia vera (PV)
  • Essential thrombocythemia (ET)
  • Primary myelofibrosis (PMF)

Differential diagnosis of these disorders is critical to selecting the appropriate therapy for your patient. In addition to utilizing our state-of-the-art testing facilities, Versiti’s experienced team will work closely with you in test utilization decisions, test result interpretation and treatment selection.

An integrated, innovative suite of tests. Versiti’s MPN testing algorithm uses an integrated suite of molecular tests that detect three markers directly associated with MPNs.

Molecular diagnostic algorithm for MPNs

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CALR Mutation Analysis

Calreticulin (CALR) somatic mutations provide a diagnostic marker in JAK2/MPL wild type essential thrombocythemia (ET) and primary myelofibrosis (PMF).

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JAK2 Exon 12 Mutation Analysis

Molecular test to detect mutations in Myeloproliferative Neoplasm (MPN) disorders. These disorders may include Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF).

4617

JAK2 V617F Mutation Analysis

Molecular test to detect mutations in Myeloproliferative Neoplasm (MPN) disorders. These disorders may include Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF).

4642

MPL Exon 10 Mutation Analysis

Molecular test to detect mutations in Myeloproliferative Neoplasm (MPN) disorders. These disorders may include Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF). This test detects common variants of codon 515 as well as novel variants within exon 10 and the adjacent intron boundaries.

4644

MPN Reflex (ET/PMF)

JAK2 V617F Mutation Analysis is always performed. If JAK2 V617F is negative, CALR Mutation Analysis is performed at an additional charge. If no CALR mutation is detected, MPL Exon 10 Mutation Analysis is performed at an additional charge.

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MPN Reflex (PV)

JAK2 V617F Mutation Analysis is always performed. JAK2 Exon 12 Mutation Analysis is performed at an additional charge if JAK2 V617F is negative. Refer to JAK2 Exon 12 for test information.

 
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