Research

Translational Research of Leukemia

 

The Deininger lab’s expertise focuses on translational research in leukemia, specifically the biology of myeloproliferative neoplasms and the development of molecular targeted therapies. We are especially interested in developing novel, anti-neoplastic targeted therapies in myeloid leukemia, as well as understanding the molecular mechanisms of cancer stem cell persistence and leukemia drug resistance.

Our lab orchestrates a multidisciplinary cancer research program, straddling genetics, biochemistry, molecular biology, pharmacology and biomedical engineering. We are proud of our vibrant team of scientists who strive to improve the diagnosis, deep analysis and therapeutics of myeloid leukemia.

Deininger Laboratory Research Projects

Strategies to Target BCR-ABL1 Compound Mutants

Strategies to target BCR-ABL1 compound mutants in CML and Ph+ ALL

Targeting the Metabolic Regulator SIRT5 in Acute Myeloid Leukemia

Targeting the Metabolic Regulator SIRT5 in Acute Myeloid Leukemia

A Bioluminescent Assay for Direct Measurement of Sirtuin Activity in Cancer Cells

A Bioluminescent Assay for Direct Measurement of Sirtuin Activity in Cancer Cells

The Function of MS4A3 in Normal and Malignant Hematopoiesis

Function of MS4A3

 
Publications
Read a select list of Dr. Deiningers publications.
 
Team
Our laboratory includes research scientists, postdoctoral fellows, technicians, and undergraduate students. If you are interested in joining the team contact us.
 
Contact Us
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Versiti Blood Research Institute
Versiti Blood Research Institute investigators study blood disorders like hemophilia, blood cancers like leukemia, and other blood diseases.