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Tomorrow's Hemostatic Therapies

From Today's Research


A list of biomedical-related publications can also be viewed here.

Molecular Therapy: Method's & Clinical Development

65. siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles.

Cau MF , Ferraresso F, Seadler S, Badior K, Zhang Y, Ketelboeter LM, Ferraresso M, Wietrzny A, Robertson M, Haugen A, Cullis PR, de Moya M, Dyer M, Kastrup CJ

Molecular Therapy - Methods & Clinical Development. Accepted 4-8-24

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64. Lipid nanoparticles and siRNA targeting plasminogen provide long-acting inhibition of fibrinolysis in murine and canine models of hemophilia A.

Strilchuk AW, Batty P, Hur WS, Sang Y, Abrahams SR, Yong ASM, Leung J, Silva LM, Schroeder JA, de Laat B, Moutsopoulos NM, Bugge TH, Shi Q, Cullis PR, Merricks EP, Wolberg AS, Flick MJ, Lillicrap D, Nichols TC, Kastrup CJ

Science Translational Medicine. 2024 Feb 21;16(735):eadh0027.doi:10.1126/scitranslmed.adh0027. Epub 2024 Feb 21.

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63. Genetically Engineered Transfusable Platelets using mRNA-Lipid Nanoparticles

Leung J, Strong C, Badior KE, Robertson M, Wu X, Meledeo MA, Kang E, Paul M, Sato Y, Harashima H, Cap AP, Devine DV, Jan E, Cullis PR, Kastrup CJ

Science Advances, (2023) – In Press

Journal of Military, Veteran and Family Health

62. Efficacy and safety of CounterFlow in animal models of hemorrhage

Peng N, Yeh N, Khavari A, Cau MF, Ali-Mohamad N, Tenn C, Semple HA, Beckett A, Kastrup CJ

Journal of Military, Veteran and Family Health, 2023, 9:1 25-39.

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61. Self-propelling thrombin powder enables hemostasis with no observable rebleeding or thrombosis over three days in a porcine model of upper gastrointestinal bleeding.

Ali-Mohamad N., Cau M., Zenova V., Baylis JR., Beckett A., McFadden A., Donnellan F., Kastrup CJ.

Gastrointestinal Endoscopy. 2023 Aug;98(2):245-248. doi: 10.1016/j.gie.2023.04.007.

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60. Ruggedized Self-Propelling Hemostatic Gauze Delivers Low Dose of Thrombin and Systemic Tranexamic Acid and Achieves High Survival in Swine with Junctional Hemorrhage.

Ali-Mohamad N.*, Cau M.*, Wang X., Khavari A., Ringgold K., Naveed A., Sherwood C., Peng N., Zhang Gau H., Zhang Y., Semple H., Peng H., Tenn C., Baylis JR., Beckett A., White NJ., Kastrup CJ.

Military Medicine, Volume 188, Issue Supplement_6, November/December 2023, Pages 280–287,

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59. Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage

Bao G, Gao Q, Cau M, Ali-Mohamad N, Strong M, Jiang S, Yang Z, Valiei A, Ma Z, Amabili M, Gao ZH, Mongeau L, Kastrup CJ, (Co-Corresponding Author)Li J

Nature Communications, 2022 13(1):5035. doi: 10.1038/s41467-022-32803-1

58. Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies

Hur WS, King kc, Patel YN, Nguyen YV, Wei C, Juang LJ, Leung J, Kastrup CJ, Wolberg AS, Luyendyk JP, Flick MJ

Journal of Thrombosis and Haemostasis, 2022, Sep 15;. doi: 10.1111/jth.15877

57. Hemostatic powders for gastrointestinal bleeding: a review of old, new, and emerging agents in a rapidly advancing field.

Jiang SX, Chahal D, Ali-Mohamad N, Kastrup C, Donnellan F

Endoscopy International Open, 2022, 10: E1136–E1146 DOI 10.1055/a-1836-8962

56. Percutaneous delivery of self-propelling thrombin-containing powder increases survival from non-compressible truncal hemorrhage in a swine model of dilutional coagulopathy and hypothermia

Cau MF, Ali-Mohamad N, Yeh H, Baylis JR, Peng H, Zhang Gao H, Rezende-Neto J, Grecov G, White NJ, Tenn C, Semple HA, Beckett A, Kastrup CJ

Journal of Trauma and Acute Care Surgery, 2022 doi: 10.1097/TA.0000000000003670

55. Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells

Ferraresso F, Strilchuk A, Juang LJ, Kastrup CJ

Molecular Pharmaceutics, 2022 doi: 10.1021/acs.molpharmaceut.2c00033.

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54. Suppression of fibrin(ogen)-driven pathologies through controlled knockdown by lipid nanoparticle delivery of siRNA.

Juang LJ, Hur WS, Silva L, Strilchuk A, Francisco B, Leung J, Groeneveld D, La Prairie B, Chun E, Cap A, Luyendyk J, Palumbo J, Cullis P, Bugge T, Flick M, Kastrup CJ.

Blood, 2022 139:1302-1311. doi: 10.1182/blood.2021014559

53. Videoconferencing for Large Animal Trauma Experiments During COVID-19: A Cross-Continent Experience.

Ali-Mohamad N, Cau MF, Baylis JR, Semple HA, Kastrup CJ -(Co-Corresponding Author), Beckett A.

Military Medicine, 2022 doi: 10.1093/milmed/usac032

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52. Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with a Fga truncation mutation.

Hur WS, Paul DS, Bouck EG Negrón AR, Mwiza JM, Poole LG, Cline-Fedewa HM, Clark EG, Juang LJ, Leung J, Kastrup CJ, Ugarova TP, Wolberg AS, Luyendyk JP, Bergmeier W, Flick MJ.

Blood, 2022 139(9):1374-1388. doi: 10.1182/blood.2021012537

51. Percutaneous delivery of self-propelling hemostatic powder into the closed abdomen for managing non-compressible abdominal hemorrhage.

Cau MF, Ali-Mohamad N, Baylis JR, Zenova V, Khavari A, Peng N, McFadden A, Donnellan F, Owen DR, Schaeffer DF, Nagaswami C, Litvinov R, Weisel J, Rezende-Neto J, Semple HA, Beckett A, Kastrup CJ.

Injury, 2022 53(5):1603-1609. doi: 10.1016/j.injury.2022.01.024

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50. Intimal resident macrophages prevent intravascular thrombosis associated with flow dynamics.

Hernandez GE, Ma F, Martinez G, Firozabadi NB, Salvador J, Juang LJ, Carias A, Madden P, Zhao P, López DA, Wang X, Veazey RS, Blair RV, Roy CJ, Dodson A, Zouantcha S, Cook A, Lewis MG, Reza Ardehali R, Beaudin AE, Kastrup CJ, Pellegrini M, Hope T, Flick MJ, Iruela-Arispe ML.

Nature Cardiovascular Research, 2022 Jan;1(1):67-84. doi: 10.1038/s44161-021-00006-4

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49. Fibrin is a critical regulator of neutrophil effector function at mucosal barriers.

Silva LM, Doyle AD, Greenwell-Wild T, Dutzan N, Tran CL, Abusleme L, Juang LJ, Leung J, Chun EM, Lum AG, Agler CS, Zuazo C, Sibree M, Jani P, Kram V, Martin D, Moss K, Lionakis M, Castellino FJ, Kastrup CJ, Flick MJ, Divaris K, Bugge TH, Moutsopoulos NM.

Science, 2021, 374 (6575), DOI: 10.1126/science.abl5450

Kastrup Lab Publication Illustration

48. Fracture Mechanics of Human Blood Clots: Measurements of Toughness and Critical Length Scales.

Liu S, Bao G, Ma Z, Kastrup CJ, Li J.

Extreme Mechanics Letters, 2021, Accepted and In Press.

Kastrup Lab Publication Illustration

47. Emerging gene therapies for enhancing the hemostatic potential of platelets.

Leung J, Cau M, Kastrup CJ.

Transfusion, 2021, 61(S1): S275-S285.

Kastrup Publication Illustration

46. Severe Upper Gastrointestinal Bleeding is Halted by Endoscopically Delivered Self-Propelling Thrombin Powder: A Porcine Pilot Study.

Ali-Mohamad N, Cau M, Baylis JR, Zenova V, Semple H, Beckett A, McFadden A, Donnellan F, Kastrup C.

Endoscopy Open International, 2021, E693-E698.

Kastrup Lab Publication Illustration

45. Nanomedicines for Hemorrhage Control.

Cau MF, Strilchuk AW, Kastrup CJ.

Journal of Thrombosis and Haemostasis, 2021 Apr;19(4):887-891 (IF 4.6)

Kastrup Lab Publication Illustration

44. Sustained Depletion of FXIII-A by Inducing Acquired FXIII-B Deficiency.

Strilchuk AW, Meixner SC, Leung J, Safikhan NS, Kulkarni JA, Russell HM, van der Meel R, Sutherland MR, Owens AP, Palumbo J, Conway EM, Pryzdial ELG, Cullis PR, Kastrup CJ.

Blood, 136 (25): 2946–2954.

Kastrup Lab Publication Illustration

43. The Evolution of Factor XI and the Kallikrein-Kinin System.

Ponczek M, Shamanaev A, Dickeson S, LaPlace A, Sun MF, Gruber A, Kastrup C, Emsley J, Gailani D.

Blood Advances, 4 (24): 6135–6147.

Kastrup Publication Illustration

42. Post-Translational Modifications of Platelet–Derived Amyloid Precursor Protein by Coagulation Factor XIII-A*.

Hur WS, Juang LJ, Mazinani N, Munro L, Jefferies WA, Kastrup CJ.

Biochemistry, 59, 46, 4449–4455.

Kastrup Publication Illustration

41. The Adhesion of Clots in Wounds Contributes to Hemostasis and can be Enhanced by Coagulation Factor XIII.

Chan KYT, Yong ASM, Wang X, Ringgold KM, St. John AE, Baylis JR, White NJ, Kastrup CJ

Scientific Reports, 10, 20116.

Kastrup Publication Illustration

40. FXII Contributes to Hemostasis when Activated by Soil in Wounds.

Juang LJ, Mazinani N, Novakowski SK, Prowse ENP, Haulena M, Gailani D, Lavkulich L, Kastrup CJ.

Blood Advances, 4 (8): 1737–1745.

In the News

"Soil in wounds can help stem deadly bleeding" , UBC Faculty of Medicine, Apr. 27, 2020. (Also reposted on EurekAlert!, ScienceDaily, NewAtlas, ZME Science, and others.)

Kastrup Publication Illustration

39. Diatom Frustule Silica Exhibits Superhydrophilicity and Superhemophilicity.

Lee J, Lee, H, Shin, M, Juang LJ, Kastrup CJ, Go GM, Lee H.

ACS Nano, 14 (4): 4755–4766.

Kastrup Publication Illustration

38. Bleeding is increased in amyloid precursor protein knockout mouse.

Mazinani N, Strilchuk AW, Hur WS, Baylis JR, Jefferies WA, Kastrup CJ.

Res Pract Thromb Haemost, 2020;00:1-6.

Kastrup Publication Illustration

37. Topical tranexamic acid is more effective when formulated with self-propelling particles.

Baylis JR, Lee MM, St. John AE, Wang X, Simonson E, Cau M, Kazerooni A, Gusti V, Statz ML, Yoon JSJ, Liggins RT, White NJ, Kastrup CJ.

J Thromb Haemost, 17(10): 1645-1654.

Kastrup Publication Illustration

36. Delivery of mRNA to Platelets using Lipid Nanoparticles.

Novakowski SK, Jiang K, Prakash G, Kastrup CJ.

Scientific Reports, 2019, 9: 552.

Kastrup Publication Illustration

35. Coagulation Factors XIII-A and XIII-A* Decrease In Some DVT Patients Following Catheter-directed Thrombolysis.

Hur WS, Warner H, Machan L, Kastrup CJ.

Blood Coagulation and Fibrinolysis, 294, 390-396.

Kastrup Publication Illustration

34. Coagulation Factor XIIIa can Crosslink Amyloid β into Dimers and Oligomers and to Blood Proteins.

Hur WS, Mazinani N, Lu XJD, Yefet LS, Byrnes JR, Ho L, Yeon JH, Filipenko S, Wolberg AS, Jefferies WA, Kastrup CJ.

Journal of Biological Chemistry (SA), 294(2): 390–396.

Kastrup Publication Illustration

33. Rivaroxaban and Apixaban Induce Clotting Factor Xa Fibrinolytic Activity.

R.L.R. Carter, K. Talbot, W.S. Hur, S.C. Meixner, J.G. Van Der Guten, D.T. Holmes, H.C.F. Cote, C.J. Kastrup, T.W. Smith, A.Y.Y. Lee, E.L.J. Pryzdial.

J Thromb Haemost 2018; 16(11): 2276-2288.

Kastrup Publication Illustration

32. Platelets loaded with liposome‐encapsulated thrombin have increased coagulability.

Chan V, Sarkari M, Sunderland R, St. John AE, White NJ, Kastrup CJ.

J Thromb Haemost 2018; 16: 1226–1235.

In the News

Team modifies platelets to improve coagulation”, Hematology Times, Apr. 13, 2018.

Look! Down in the petri dish! It’s a super platelet!”, UBC Faculty of Medicine, Apr. 11, 2018, (Also reposted on Apr. 12, 2018 – Science Daily).

Jan. 14, 2017 – Bowen Island Undercurrent

Local researcher developing new technology to stop post-partum bleeding”.

Kastrup Publication Illustration

30. Localization of short-chain polyphosphate enhances its ability to clot flowing blood plasma.

J.H. Yeon, N. Mazinani, T.S. Schlappi, K.Y.T. Chan, J.R. Baylis, S.A. Smith, A.J. Donovan, D. Kudela, G.D. Stucky, Y. Liu, J.H. Morrissey, C.J. Kastrup.

Scientific Reports, 2017: 7: 42119.

Kastrup Publication Illustration

29. Rapid hemostasis in a sheep model using particles that propel thrombin and tranexamic acid.

J.R. Baylis, A. Finkelstein-Kulka, L. Macias-Valle, J. Manji, M. Lee, E. Levchenko, C. Okpaleke, S. Al-Salihi, A. Javer, C.J. Kastrup.

The Laryngoscope, 2017: 127(4): 787-793.

In the News

Dec. 6, 2016 – UBC Faculty of Medicine

Christian Kastrup wins Banting Award from True Patriot Love Foundation” by Brian Kladko.

Dec. 6, 2016 – UBC Faculty of Medicine

Christian Kastrup wins Banting Award from True Patriot Love Foundation” by Brian Kladko.

Kastrup Publication Illustration

28. Thrombolysis by chemically modified coagulation factor Xa.

E.L. Pryzdial, S.C. Meixner, K. Talbot, L.J. Eltringham-Smith, J.R. Baylis, F.M. Lee, C.J. Kastrup, W.F. Sheffield.

Journal of Thrombosis and Haemostasis, 2016: 14(9): 1844-1854.

Kastrup Publication Illustration

27. Halting hemorrhage with self-propelling particles and local drug delivery.

J.R. Baylis, K.Y.T. Chan, C.J. Kastrup.

Thrombosis Research, 2016: 141(Suppl 2): S26-S39

Kastrup Publication Illustration

26. Adhesion of blood clots can be enhanced when copolymerized with a macromer that is cross-linked by coagulation factor XIIIa.

K.Y.T. Chan, C.Y. Zhao, E.M.J. Siren, J.C.Y. Chan, J. Boschman, C.J. Kastrup.

Biomacromolecules, 2016: 17(6): 248–2252.

In the News

Jul. 15, 2016 – UBC Faculty of Science, UBC Faculty of Medicine

UBC researchers in vent a synthetic ‘glue’ for blood clots” by Bryan Kladko

Kastrup Publication Illustration

25. Self-propelled dressings containing thrombin and tranexamic acid improve short-term survival in a swine model of lethal junctional hemorrhage.

J.R. Baylis, A.E. St. John, X. Wang, E.B. Lim, M.L. Statz, E. Simonson, S.A. Stern, R.T. Liggins, N.J. White, C.J. Kastrup.

Shock: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, 2016: 46(3 Suppl 1): 123-128.

Kastrup Publication Illustration

24. Coagulation Factor XIIIa is Inactivated by Plasmin.

W.S. Hur, N. Mazinani, X.J.D. Lu, H.M. Britton, J.R. Byrnes, A.S. Wolberg, C.J. Kastrup.

Blood, 2015: 126(20): 2329-2337.

In the News

Nov. 12, 2015 – Blood Commentaries

D.H. Farrell, “Lucky 13”, Blood, 126(20):2261-2. doi: 10.1182/blood-2015-09-670471.

Kastrup Publication Illustration

23. Controlled transcription of exogenous mRNA in platelets using protocells.

V. Chan, S.K. Novakowski, S. Law, C. Klein-Bosgoed, C.J. Kastrup.

Angewandte Chemie, 2015: 54(46):13590–13593.

In the News

UBC makes leap with blood cells”, Vancouver 24 hrs (local newspaper), Nov. 12, 2015

Platelets engineered to deliver, transcribe RNA”, Science & Enterprise, Nov. 5, 2015

UBC researchers transform humble blood cells into ‘Franken-platelets’” EurekAlert!, Nov. 4, 2015

Behold UBC’s latest creation: the “Frankenplatelet”, UBC Faculty of Medicine, Nov. 4, 2015

Kastrup Publication Illustration

22. Self-Propelling Particles that Transport Cargo Through Flowing Blood and Halt Hemorrhaging.

J.R. Baylis, J.H. Yeon, M.H. Thomson, A. Kazerooni, X Wang, A.E. St. John, E.B. Lim, D. Chien, A. Lee, J.Q. Zhang, J.M. Piret, L.S. Machan, T.F. Burke, H.J. White, C.J. Kastrup.

Science Advances, 2015: 1(9), e1500379.

In the News

Dec. 17, 2015 – Vancouver Sun “Self-propelled particles deliver clotting drugs in spite of heavy blood flow” by Randy Shore Nov. 12, 2015 – BioCentury Innovations “Self-propelling particles go upstream into wounds to stop bleeding” by Karen Tkach Oct. 8, 2015 – Naked Scientists (Podcast) “Blood clotting ‘bullets’ Oct. 6, 2015 – CTV Canada AM “UBC researchers develop powder to stop bleeding” reported by Marci Ien

Oct. 4, 2015 – News 1130 “UBC develops blood clotting powder” reported Martin Macmahon Oct. 3, 2015 – Global News BC “BC researchers develop powder that stops the bleeding” reported by Jon Azpiri

Oct. 2, 2015 – CKNW AM980 “The first of its kind: UBC creates powder to stop critical bleeding” reported by Shelby Thom Oct. 2, 2015 – WIRED “Gas-Propelled Microparticles Could Stop Bleeding in Wounds

Kastrup Publication Illustration

21. A biochemical network can control formation of a synthetic material by sensing numerous specific stimuli.

J.H. Yeon, K.Y.T. Chan, T.C. Wong, K. Chan, M. R. Sutherland, R.F. Ismagilov, E.L.G. Pryzdial, C.J. Kastrup.

Scientific Reports, 2015: (5):10274.

Kastrup Publication Illustration

20. Defects in phosphate acquisition and storage influence the virulence of Cryptococcus neoformans.

Kretschmer, E. Reiner, G. Hu, N. Tam, D.L. Oliveira, M. Caza, J.H. Yeon, J. Kim, C.J. Kastrup, W.H. Jung. J.W. Kronstad.

Infection and Immunity, 2014: 2697-2712.

Nov 23, 2012 – UBC Faculty of Medicine

“UBC Inventor of Self-Propelled Coagulant Wins Grant from Grand Challenges Canada” by Brian Kladko

Kastrup Publication Illustration

19. Painting Blood Vessels and Atherosclerotic Plaques with an Adhesive Drug Depot.

C.J. Kastrup, M. Nahrendorf, J.L. Figueiredo, H. Lee, S. Kambhampati, T. Lee, S.W. Cho, R. Gorbatov, Y. Iwamoto, T.T. Dang, P. Dutta, J.H. Yeon, H. Cheng, C.D. Pritchard, A.J. Vegas, C.D. Siegel, S. MacDougall, M. Okonkwo, J.R. Stone, A.J. Coury, R. Weissleder, R. Langer, D.G. Anderson.

Proceedings of the National Academy of Sciences. 2012 (109): 21444-9.

In the News

Mar/Apr 2013 – ACCN (Canadian Chemical News)

Mussel ‘glue’ protects damaged­ blood vessels” by Tyler Irving

Jan. 11, 2013 – Science

Editor’s Choice: “Vascular Glue” by Paula A. Kiberstis

Jan. 8, 2013 — Wonder of Science (an online magazine for high school students)

“Mussel glue makes blood vessel glue”

Jan. 2, 2013 – Science Translational Medicine

Editor’s Choice: “Bioinspired Glue for Healing Atherosclerotic Plaques” by Carsten Skarke

Dec. 12, 2012 – Global News (aired on 6 pm BC News Hour nation-wide)

“Researchers from UBC have adapted the adhesive quality from shoreline mussels into a gel for medical use” reported by Leigh Kjekstad

Dec 10, 2012 – UBC Faculty of Medicine (also featured by UBC Faculty of Science)

A mussel’s stickiness inspires invention of an adhesive gel for blood vessels” by Brian Kladko

Kastrup Publication Illustration

18. Remotely-activated Protein-Producing Nanoparticles.

Schroeder, M.S. Goldberg, C.J. Kastrup, Y. Wang, B.J. Joseph, C.G. Levins, R. Langer, D.G. Anderson.

Nano Letters, 2012 (12):2685-2689.

Kastrup Publication Illustration

17. Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics.

Cheng, M. Byrska-Bishop, C.T. Zhang, C.J. Kastrup, N.S. Hwang, W.W. Lee, X. Xu, M.P. Nahrendorf, R. Langer, D.G. Anderson.

Biomaterials, 2012 (33): 5004-12.

Kastrup Publication Illustration

16. Rapid Discovery of Potent siRNA-Lipid-Nanoparticles Enabled by Controlled Microfluidic Formulation.

Chen, K. Love, Y. Chen, A. Eltoukhy, C.J. Kastrup, Christian; G. Sahay, A. Jeon, D. Yizhou, K. Whitehead, D.G. Anderson.

Journal of the American Chemical Society, 2012 (134): 6948-6951.

15. Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery.

Cheng, C.J. Kastrup, R. Ramanathan, D.J. Siegwart, M.L. Ma, S.R. Bogatyrev, Q.B. Xu, K.A. Whitehead, R. Langer, D.G. Anderson.

ACS Nano, 2010 (4): 625-631.

14. Confinement Regulates Complex Biochemical Networks: Initiation of Blood Clotting by “Diffusion Acting”.

Shen, C.J. Kastrup, R.R. Pompano, R.F. Ismagilov.

Biophysical Journal, 2009 (97): 2137-2135.

13. Spatial Localization of Bacteria Controls Initiation of Blood Coagulation by “Quorum Acting”

C.J. Kastrup, J.Q. Boedicker, A.P. Pomerantsev, M. Moayeri, Y. Bian, R.R. Pompano, T.R. Kline, F. Shen, W.-J. Tang, S.H. Leppla, R.F. Ismagilov.

Nature Chemical Biology, 2008 (4): 742-750.

12. Threshold Response of Initiation of Blood Coagulation by Tissue Factor in Patterned Microfluidic Capillaries is Controlled by Shear Rate.

Shen, C.J. Kastrup, Y. Liu, R.F. Ismagilov.

Arteriosclerosis Thrombosis and Vascular Biology, 2008 (28): 2035-2041.

11. The Effects of Shear Rate on Propagation of Blood Clotting Determined Using Microfluidics and Numerical Simulations.

M.K. Runyon, C.J. Kastrup, B. Johnson-Kerner, T.G. Van Ha, R.F. Ismagilov.

Journal of the American Chemical Society, 2008 (130): 3458-3464.

10. Using Microfluidics to Understand the Effect of Spatial Distribution of Tissue Factor on Blood Coagulation.

Shen, C.J. Kastrup, R.F. Ismagilov.

Thrombosis Research, 2008 (121) S27-S30.

09. A physical-organic mechanistic approach to understanding the complex reaction network of hemostasis (blood clotting).

C.J. Kastrup, R.F. Ismagilov.

Journal of Physical Organic Chemistry, 2007 (20): 711-715.

08. Using Chemistry and Microfluidics to Understand the Spatial Dynamics of Complex Biological Networks.

C.J. Kastrup, M.K. Runyon, E.M. Lucchetta, R.F. Ismagilov.

Accounts of Chemical Research, 2007 (41): 549-558.

07. Characterization of the Threshold Response of Initiation of Blood Clotting to Stimulus Patch Size.

C.J. Kastrup, F. Shen, R.F. Ismagilov.

Biophysical Journal, 2007 (93): 2969-2977.

06. Simple Chemistry Identifies Mechanism for Localization of Blood Clots in Complex Network of Hemostasis.

M.K. Runyon, B. Johnson-Kerner, C.J. Kastrup, T.G. Van Ha, R.F. Ismagilov.

Journal of the American Chemical Society, 2007 (129): 7014-7015.

05. Response to shape emerges in a complex biochemical network and its simple chemical analogue.

C.J. Kastrup, F.Shen, R.F. Ismagilov.

Angewandte Chemie International Edition, 2007 (46): 3660-3662.

04. Modular Chemical Mechanism Predicts Spatiotemporal Dynamics of Initiation in the Complex Network of Hemostasis.

C.J. Kastrup, M.K. Runyon, F.Shen, R.F. Ismagilov.

Proceedings of the National Academy of Sciences, 2006 (103): 15747-15752.

03. The aromaticity and Möbius characteristics of carbeno[8] heteroannulenes and triplet state annulenes.

C.J. Kastrup, S.V. Oldfield, H.S. Rzepa.

Chemical Communications, 2002 (6): 642-643.

02. An ab initio computational study of monodentate palladium ligand complexes with Mobius-aromatic chiral character.

C.J. Kastrup, S.V. Oldfield, H.S. Rzepa.

Journal of the Chemical Society-Dalton Transactions, 2002 (12): 2421-2422.

01. Möbius aromatic forms of 8-pi electron heteropine.

W.L. Karney, C.J. Kastrup, S.V. Oldfield, H.S. Rzepa.

Journal of the Chemical Society-Perkin Transactions 2, 2002 (3): 388-392.

This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Combat Readiness Medical Research Program, under Award No. W81XWH2110969. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense.

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Christian Kastrup Laboratory
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