Dr. Dittel has been published in a number of prestigious scientific and medical journals for her study of autoimmune and inflammatory diseases.
B Cell Focus
- Khalil, M., C.J. Gurski, L.J. Dittel, S.D. Neu and B.N. Dittel. 2020. Discovery and function of B cell IgD low (BDL) B cells in immune tolerance. J. Mol. Biol. doi:10.1016/j.jmb.2020.06.023.
- Ray, A., Khalil, M., Pulakanti, K.L., Burns, R.T., Gurski, C.J., Basu, S., Wang, D., Rao, S. and Dittel, B.N. 2019. Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis. Nat. Commun. doi.org/10.1038/s41467-018-08122-9
- Ray, A and B.N. Dittel. 2017. Mechanisms of regulatory B cell function in autoimmune and inflammatory diseases beyond IL-10. J. Clin. Med. 6, 12; doi:10.3390/jcm6010012
- Ray, A., C.Y. Yuan, N.M. Miller, H. Mei and B.N. Dittel. 2015. 2B4 is dispensable for T-dependent B cell immune responses, but its deficiency leads to enhanced T-independent responses due to an increase in peritoneal cavity B1b cells. PLoS ONE. 10(8):e0137314. doi: 10.1371/journal.pone.0137314.
- Ray, A., S. Basu, R.Z. Gharaibeh, L.C. Cook, R. Kumar, E.J. Lefkowitz, C.R. Walker, C.D. Morrow, C.L. Franklin, T.L. Geiger, N.H. Salzman, A.F. Fodor and B.N. Dittel. 2015. Gut microbioal dysbiosis due to Helicobacter drives and increase in marginal zone B cell in the absence of IL-10 signaling in macrophages. J. Immunol. 195:3071-3085.
- Ray, A., L. Wang, and B.N. Dittel. 2015. IL-10-independent regulatory B cell subsets and mechanism of action. Int. Immunol. doi: 10.1093/intimm/dxv033.
- Wang, L., A. Ray, X. Jiang, J-Y. Wang, S. Basu, X. Liu, T. Qian, B.N. Dittel* and Y. Chu*. 2015. T regulatory cells and B cells cooperate to form a regulatory loop that maintains gut homeostasis and suppresses dextran sulfate sodium-induced colitis. Mucosal Immunol. 8:1297-1312.
- Basu, S., A. Ray and B.N. Dittel. 2013. Differential representation of B cell subsets in mixed bone marrow chimera mice due to expression of allelic variants of CD45 (CD45.1/CD45.2). J. Immunol. Meth. 396:163-167.
- Basu, S., A. Ray and B.N. Dittel. 2013. Cannabinoid receptor 2 (CB2) plays a role in the generation of germinal center and memory B cells, but not in the production of antigen-specific IgG and IgM, in response to T-dependent antigens. PLoS ONE 8(6): e67587. doi:10.1371/journal.pone.0067587.
- Mann, M.K., A. Ray, S. Basu, C. Karp and B.N. Dittel. 2012. Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis. Autoimmun. 45:388-399.
- Ray, A., S. Basu, C. Williams, N. Salzman and B.N. Dittel. 2012. A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITRL. J. Immunol. 188:3188-3198.
Selected for Faculty of 1000.
- Basu, S., Ray, A, and B.N. Dittel. 2011. Cannabinoid receptor 2 (CB2) is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses. J. Immunol. 187:5720-5732.
- Ray, A., M.K. Mann, S. Basu, and B.N. Dittel. 2011. A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis. J. Neuroimmunol. 230:1-9.
- Mann, M.K., K. Maresz, L.P. Shriver, T. Tan, and B.N. Dittel. 2007. B cell regulation of CD4+CD25+ T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis. J. Immunol. 178:3447-3456.
Other Significant Scientific Contributions
- Klein R.S., R. Voskuhl B.M. Segal, B.N. Dittel, T.E. Lane, J.R. Bethea, M.J. Carson, C. Colton, S. Rosi, A. Anderson, L. Piccio, J.M. Goverman, E.N. Benveniste, M.A. Brown, S.K. Tiwari-Woodruff, T.H. Harris, A.H. Cross. 2017. Speaking out about gender imbalance in invited speakers improves diversity. Nat. Immunol. 18:475-478.
- Zhang, H., A. Ray, N.M. Miller, D. Hartwig, K.A. Pritchard, Jr., and B.N. Dittel. 2015. Inhibition of myeloperoxidase at the peak of experimental autoimmune encephalomyelitis restores blood-brain-barrier integrity and ameliorates disease severity. J. Neurochem. 136:826-836.
- Miller, N., L.P. Shriver, V.L. Bodiga, A. Ray, S. Basu, R. Ahuja, A. Jana, K. Pahan and B.N. Dittel. 2013. Lymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal death. ASN NEURO. e00105. doi:10.1042/AN20120087
- Maresz, K. G. Pryce, E.D. Ponomarev, G. Marsicano, J.L. Croxford, L.P. Shriver, C. Ledent, X. Cheng, E. Carrier, Mann, M.K., G. Giovannoni, R.G. Pertwee, T. Yamamura, N.E. Buckley, C.J. Hillard, B. Lutz, D. Baker and B.N. Dittel. 2007. Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat. Med. 13:492-497.
- Ponomarev, E.D., L.P. Shriver, K. Maresz, J. Pedras-Vasconcelos, D. Verthelyi and B.N. Dittel. 2007. GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis. J. Immunol. 178:39-48.
- Shriver, L.P. and B.N. Dittel. 2006. T cell-mediated disruption of the neuronal microtubule network: Correlation with early reversible axonal dysfunction in acute experimental autoimmune encephalomyelitis. Amer. J. Path. 169:999-1011.
- Ponomarev, E.D., L.P. Shriver and B.N. Dittel. 2006. CD40 expression by microglial cells is required for their completion of a two-step activation process during CNS autoimmune inflammation. J. Immunol. 176:1402-1410.
- Ponomarev, E.D., L.P. Shriver, K. Maresz, and B.N. Dittel. 2005. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J. Neurosci. Res. 81:374-389.
- Maresz, K., E.J. Carrier, E.D. Ponomarev, C.J. Hillard, and B.N. Dittel. 2005. Modulation of the endocannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli. J. Neurochem. 95:437-445.
Top ten cited article for J. Neurochem. published in 2005
- Ponomarev, E.D., M. Novikova, K. Maresz, L.P. Shriver, and B.N. Dittel. 2005. Development of a culture system that supports adult microglial cell proliferation and maintenance in the resting state. J. Immunol. Meth. 300:32-46.