Versiti - Publications | Bonnie Dittel Laboratory | Versiti Blood Research Institute



Dr. Dittel has been published in a number of prestigious scientific and medical journals for her study of autoimmune and inflammatory diseases.

B Cell Focus

  1. Khalil, M., C.J. Gurski, L.J. Dittel, S.D. Neu and B.N. Dittel. 2020. Discovery and function of B cell IgD low (BDL) B cells in immune tolerance. J. Mol. Biol. doi:10.1016/j.jmb.2020.06.023.
  2. Ray, A., Khalil, M., Pulakanti, K.L., Burns, R.T., Gurski, C.J., Basu, S., Wang, D., Rao, S. and Dittel, B.N. 2019. Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis. Nat. Commun.
  3. Ray, A and B.N. Dittel. 2017. Mechanisms of regulatory B cell function in autoimmune and inflammatory diseases beyond IL-10. J. Clin. Med. 6, 12; doi:10.3390/jcm6010012
  4. Ray, A., C.Y. Yuan, N.M. Miller, H. Mei and B.N. Dittel. 2015. 2B4 is dispensable for T-dependent B cell immune responses, but its deficiency leads to enhanced T-independent responses due to an increase in peritoneal cavity B1b cells. PLoS ONE. 10(8):e0137314.  doi: 10.1371/journal.pone.0137314.
  5. Ray, A., S. Basu, R.Z. Gharaibeh, L.C. Cook, R. Kumar, E.J. Lefkowitz, C.R. Walker, C.D. Morrow, C.L. Franklin, T.L. Geiger, N.H. Salzman, A.F. Fodor and B.N. Dittel.  2015. Gut microbioal dysbiosis due to Helicobacter drives and increase in marginal zone B cell in the absence of IL-10 signaling in macrophages. J. Immunol.  195:3071-3085.
  6. Ray, A., L. Wang, and B.N. Dittel. 2015. IL-10-independent regulatory B cell subsets and mechanism of action. Int. Immunol. doi: 10.1093/intimm/dxv033.
  7. Wang, L., A. Ray, X. Jiang, J-Y. Wang, S. Basu, X. Liu, T. Qian, B.N. Dittel* and Y. Chu*. 2015. T regulatory cells and B cells cooperate to form a regulatory loop that maintains gut homeostasis and suppresses dextran sulfate sodium-induced colitis. Mucosal Immunol. 8:1297-1312.
    *Co-senior authors.
  8. Basu, S., A. Ray and B.N. Dittel. 2013. Differential representation of B cell subsets in mixed bone marrow chimera mice due to expression of allelic variants of CD45 (CD45.1/CD45.2). J. Immunol. Meth. 396:163-167.
  9. Basu, S., A. Ray and B.N. Dittel. 2013. Cannabinoid receptor 2 (CB2) plays a role in the generation of germinal center and memory B cells, but not in the production of antigen-specific IgG and IgM, in response to T-dependent antigens. PLoS ONE 8(6): e67587. doi:10.1371/journal.pone.0067587.
  10. Mann, M.K., A. Ray, S. Basu, C. Karp and B.N. Dittel. 2012. Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis. Autoimmun. 45:388-399.
  11. Ray, A., S. Basu, C. Williams, N. Salzman and B.N. Dittel. 2012. A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITRL. J. Immunol. 188:3188-3198.
    Selected for Faculty of 1000.
  12. Basu, S., Ray, A, and B.N. Dittel. 2011. Cannabinoid receptor 2 (CB2) is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses. J. Immunol. 187:5720-5732.
  13. Ray, A., M.K. Mann, S. Basu, and B.N. Dittel. 2011. A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis. J. Neuroimmunol. 230:1-9.
  14. Mann, M.K., K. Maresz, L.P. Shriver, T. Tan, and B.N. Dittel. 2007.  B cell regulation of CD4+CD25+ T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis.  J. Immunol. 178:3447-3456.

Other Significant Scientific Contributions

  1. Klein R.S., R. Voskuhl B.M. Segal, B.N. Dittel, T.E. Lane, J.R. Bethea, M.J. Carson, C. Colton, S. Rosi, A. Anderson, L. Piccio, J.M. Goverman, E.N. Benveniste, M.A. Brown, S.K. Tiwari-Woodruff, T.H. Harris, A.H. Cross. 2017. Speaking out about gender imbalance in invited speakers improves diversity. Nat. Immunol. 18:475-478.
  2. Zhang, H., A. Ray, N.M. Miller, D. Hartwig, K.A. Pritchard, Jr., and B.N. Dittel. 2015. Inhibition of myeloperoxidase at the peak of experimental autoimmune encephalomyelitis restores blood-brain-barrier integrity and ameliorates disease severity. J. Neurochem. 136:826-836.
  3. Miller, N., L.P. Shriver, V.L. Bodiga, A. Ray, S. Basu, R. Ahuja, A. Jana, K. Pahan and B.N. Dittel. 2013. Lymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal death. ASN NEURO. e00105. doi:10.1042/AN20120087
  4. Maresz, K. G. Pryce, E.D. Ponomarev, G. Marsicano, J.L. Croxford, L.P. Shriver, C. Ledent, X. Cheng, E. Carrier, Mann, M.K., G. Giovannoni, R.G. Pertwee, T. Yamamura, N.E. Buckley, C.J. Hillard, B. Lutz, D. Baker and B.N. Dittel.  2007.  Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat. Med. 13:492-497.
  5. Ponomarev, E.D., L.P. Shriver, K. Maresz, J. Pedras-Vasconcelos, D. Verthelyi and B.N. Dittel. 2007. GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis. J. Immunol. 178:39-48.
  6. Shriver, L.P. and B.N. Dittel. 2006. T cell-mediated disruption of the neuronal microtubule network: Correlation with early reversible axonal dysfunction in acute experimental autoimmune encephalomyelitis. Amer. J. Path. 169:999-1011.
  7. Ponomarev, E.D., L.P. Shriver and B.N. Dittel. 2006. CD40 expression by microglial cells is required for their completion of a two-step activation process during CNS autoimmune inflammation. J. Immunol. 176:1402-1410.
  8. Ponomarev, E.D., L.P. Shriver, K. Maresz, and B.N. Dittel. 2005. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J. Neurosci. Res. 81:374-389.
  9. Maresz, K., E.J. Carrier, E.D. Ponomarev, C.J. Hillard, and B.N. Dittel. 2005. Modulation of the endocannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli. J. Neurochem. 95:437-445.
    Top ten cited article for J. Neurochem. published in 2005
  10. Ponomarev, E.D., M. Novikova, K. Maresz, L.P. Shriver, and B.N. Dittel. 2005. Development of a culture system that supports adult microglial cell proliferation and maintenance in the resting state. J. Immunol. Meth. 300:32-46.

Complete list of Published Work in MyBibliography

Awards and Patents
Bonnie Dittel, PhD, has received a number of awards and patents for her research of autoimmune diseases like multiple sclerosis.
Datasets and Protocols
Dr. Dittel has published a number of datasets and protocols, including B cell subsets, RNA-seq data, cell populations and more.
Dittel lab personnel work in a collaborative environment and share knowledge to advance groundbreaking science.
News and Media
News and media highlights about Bonnie Dittel, PhD, including her research of multiple sclerosis at Versiti Blood Research Institute.