• Platelet activation and thrombus formation in the setting of inflammation
• Risk factors and prevention strategies for hospital-acquired thrombosis in children

Active Support

Grant: 1K08HL146941 – Mentored Clinical Science Research Award

• Source: National Institutes of Health, National Heart, Lung, and Blood Institute
• Role: PI (75% effort)
• Dates: 1/2019 – 6/2025
• Direct funds: $894,911
• Project Title: The Role of Inflammation in Platelet Signaling and Thrombosis
• Project Aim: To investigate the signaling mechanisms underlying platelet activation and thrombosis in the context of clinical inflammation.

Grant: MACC Fund Award

• Source: Medical College of Wisconsin/Midwest Athletes Against Childhood Cancer
• Role: PI
• Dates: 7/2023 – 6/2024
• Direct funds: $23,539
• Project Title: GAS6 in human platelets and plasma
• Project Aim: To identify location of GAS6 and evaluate activity in human platelets and plasma

Grant: Joan C. Gill Pilot Award

• Source: Versiti Comprehensive Center for Blood Disorders
• Role: PI
• Dates: 07/2023-06/2022
• Direct funds: $50,000
• Project Title: CHAT All-Hospital HA-VTE Risk Assessment Model Validation
• Project Aim: Prospective validation of a published hospital-wide risk assessment model for hospital-acquired venous thromboembolism.

Pending Support

Grant: NIH R03

• Source: NHLBI
• Role: PI
• Dates: 07/2024-06/2026
• Direct funds: $150,000
• Project Title: Role of Protein S-TAM to Platelet Activation Signaling and Thrombus Formation
• Project Aim: Determine relative contributions of GAS6 and protein S to platelet activation signaling in thromboimflammation

Stephanie Springborn, BS, MS
Lab Manager, Senior Research Technologist

Marjorie Kipp, BS
Laboratory Animal Technician

Dikshita Ramesh
Research Technologist

Click Here for a full list of publications from Dr. Brian R Branchford

Selected Publications

1. Branchford BR and Carpenter, S. The role of inflammation in venous thrombosis. Front Pediatr. 2018. eCollection 2018. Review. PMID: 29876337.
2. Law L, Graham D, Di Paola J, Branchford BR. GAS6/TAM pathway signaling in hemostasis and thrombosis. Front. Med. (Lausanne) 2018. eCollection 2018. Review. PMID: 29868590.
3. Zhang W, McIver AL, Stashko MA, DeRyckere D, Branchford BR, Hunter D, Kireev D, Miley MJ, Norris-Drouin J, Stewart WM, Lee M, Sather S, Zhou Y, Di Paola JA, Machius M, Janzen WP, Earp HS, Graham DK, Frye SV, Wang X. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem. 2013 Dec 12;56(23):9693-700. PMID: 24219778; PMCID: PMC3962266.
4. Branchford BR, Stalker TJ, Law L, Acevedo G, Sather S, Brzezinski C, Wilson KM, Minson K, Lee-Sherick AB, Davizon-Castillo P, Ng C, Zhang W, Neeves KB, Lentz SR, Wang X, Frye SV, Earp HS, DeRyckere D, Brass LF, Graham DK, Di Paola JA. The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. J Thromb Haemost. 2018 Feb; 16(2):352-262. PMID: 29045015

*Commentary in J Thromb Haemost: Cosemans JMEM. At the MERcy of platelet primers. J Thromb Haemost. 2018 Feb; 16(2):349-351. PMID: 2919456

5. Jones WL, Ramos CR, Banerjee A, Moore EE, Hansen KC, Coleman JR, Kellher M, Neeves KB, Silliman CC, Di Paola J, Branchford BR. Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and deceases clot strength. Platelets. 2022. Nov 17;33(8):1119-113. 1PMID: 35659185
6. Majtan T, Park I, Cox A, Branchford BR, di Paola J, Bublil E, Kraus JP. Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine restricted diet or enzyme replacement therapy. FASEB J. 2019 Nov; 33(11): 12477-12486. PMID: 31450979
7. Kastelowitz N, Tamura R, Onasoga A, Stalker T, White O, Brown P, Brodsky G, Brass L, Branchford B, Di Paola J, Yin H. Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine. Sci Rep. 2017 Jun 27;7(1): 4275. PMID: 28655899; PMCID: PMC5487340

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