Versiti - Brian Branchford, MD | Versiti Blood Research Institute

Brian Branchford, MD

Brian  Brian  profile

Brian Branchford, MD

Associate Medical Director, Associate Investigator

Thrombosis & Hemostasis

Assistant Professor
Department of Pediatrics
Medical College of Wisconsin

Education and Training

Postdoctoral Training: University of Colorado School of Medicine, Pediatric Hem/Onc/BMT Fellowship & Platelet Activation Signaling, Jorge Di Paola Lab, 2018

Pediatrics Residency: Medical College of Wisconsin, VWF Genetics, Robert Montgomery Lab, 2009
University of WIsconsin School of Medicine and Public Health, 2005

Program Specialty:

Pediatric Hematology - Oncology

Board Certifications

American Board of Pediatrics
American Board of Pediatric Hematology – Oncology

Contact Information
  • 414-257-2424
  • 414-257-2424
    • Platelet activation and thrombus formation in the setting of inflammation
    • Risk factors and prevention strategies for hospital-acquired thrombosis in children
    Active Support

    Grant: 1K08HL146941 – Mentored Clinical Science Research Award

    • Source: National Institutes of Health, National Heart, Lung, and Blood Institute
    • Role: PI (75% effort)
    • Dates: 1/2019 – 6/2025
    • Direct funds: $894,911
    • Project Title: The Role of Inflammation in Platelet Signaling and Thrombosis
    • Project Aim: To investigate the signaling mechanisms underlying platelet activation and thrombosis in the context of clinical inflammation.

    Grant: MACC Fund Award

    • Source: Medical College of Wisconsin/Midwest Athletes Against Childhood Cancer
    • Role: PI
    • Dates: 7/2023 – 6/2024
    • Direct funds: $23,539
    • Project Title: GAS6 in human platelets and plasma
    • Project Aim: To identify location of GAS6 and evaluate activity in human platelets and plasma

    Grant: Joan C. Gill Pilot Award

    • Source: Versiti Comprehensive Center for Blood Disorders
    • Role: PI
    • Dates: 07/2023-06/2022
    • Direct funds: $50,000
    • Project Title: CHAT All-Hospital HA-VTE Risk Assessment Model Validation
    • Project Aim: Prospective validation of a published hospital-wide risk assessment model for hospital-acquired venous thromboembolism.
    Pending Support

    Grant: NIH R03

    • Source: NHLBI
    • Role: PI
    • Dates: 07/2024-06/2026
    • Direct funds: $150,000
    • Project Title: Role of Protein S-TAM to Platelet Activation Signaling and Thrombus Formation
    • Project Aim: Determine relative contributions of GAS6 and protein S to platelet activation signaling in thromboimflammation

    Stephanie Springborn, BS, MS
    Lab Manager, Senior Research Technologist

    Marjorie Kipp, BS
    Laboratory Animal Technician

    Dikshita Ramesh
    Research Technologist

    Click Here for a full list of publications from Dr. Brian R Branchford

    Selected Publications
    1. Branchford BR and Carpenter, S. The role of inflammation in venous thrombosis. Front Pediatr. 2018. eCollection 2018. Review. PMID: 29876337.
    2. Law L, Graham D, Di Paola J, Branchford BR. GAS6/TAM pathway signaling in hemostasis and thrombosis. Front. Med. (Lausanne) 2018. eCollection 2018. Review. PMID: 29868590.
    3. Zhang W, McIver AL, Stashko MA, DeRyckere D, Branchford BR, Hunter D, Kireev D, Miley MJ, Norris-Drouin J, Stewart WM, Lee M, Sather S, Zhou Y, Di Paola JA, Machius M, Janzen WP, Earp HS, Graham DK, Frye SV, Wang X. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem. 2013 Dec 12;56(23):9693-700. PMID: 24219778; PMCID: PMC3962266.
    4. Branchford BR, Stalker TJ, Law L, Acevedo G, Sather S, Brzezinski C, Wilson KM, Minson K, Lee-Sherick AB, Davizon-Castillo P, Ng C, Zhang W, Neeves KB, Lentz SR, Wang X, Frye SV, Earp HS, DeRyckere D, Brass LF, Graham DK, Di Paola JA. The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. J Thromb Haemost. 2018 Feb; 16(2):352-262. PMID: 29045015

    *Commentary in J Thromb Haemost: Cosemans JMEM. At the MERcy of platelet primers. J Thromb Haemost. 2018 Feb; 16(2):349-351. PMID: 2919456

    1. Jones WL, Ramos CR, Banerjee A, Moore EE, Hansen KC, Coleman JR, Kellher M, Neeves KB, Silliman CC, Di Paola J, Branchford BR. Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and deceases clot strength. Platelets. 2022. Nov 17;33(8):1119-113. 1PMID: 35659185
    2. Majtan T, Park I, Cox A, Branchford BR, di Paola J, Bublil E, Kraus JP. Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine restricted diet or enzyme replacement therapy. FASEB J. 2019 Nov; 33(11): 12477-12486. PMID: 31450979
    3. Kastelowitz N, Tamura R, Onasoga A, Stalker T, White O, Brown P, Brodsky G, Brass L, Branchford B, Di Paola J, Yin H. Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine. Sci Rep. 2017 Jun 27;7(1): 4275. PMID: 28655899; PMCID: PMC5487340



    Thrombosis & Hemostasis
    We study the properties of blood that cause it to clot. Our findings help to treat diseases that cause blood clots or excessive bleeding.
    Join Versiti Blood Research Institute
    Versiti Blood Research Institute, located in Milwaukee, Wisconsin, includes basic and clinical researchers in a variety of blood health fields.
    Our Investigators
    Browse our Investigators, Emeritus Investigators, and other members of the Blood Research Institute.
    Versiti Blood Research Institute
    Versiti Blood Research Institute investigators study blood disorders like hemophilia, blood cancers like leukemia, and other blood diseases.