The Bioinformatics team is led by Tongjun Gu, PhD, Director of the Bioinformatics Core and Associate Investigator, who brings extensive expertise in bioinformatics and biostatistical methods and in the development of AI tools for the analysis of large biomedical and clinical data sets.

To contact the Bioinformatics group and submit questions about services prior to accessing this resource via iLab, email bioinformaticscore@versiti.org or visit us during walk-in office hours every Tuesday and Thursday between 1-2 p.m. We are located at West Side of the 2nd floor at VBRI.

The Bioinformatics Core offers comprehensive support throughout the lifecycle of scientific projects, from experimental design to data analysis, result interpretation, and dissemination of findings. We also collaborate closely with other Shared Resources on joint projects and offer end-to-end bioinformatics assistance. Our capabilities encompass the development and operation of standard and advanced data processing pipelines, covering tasks such as bulk next-generation sequencing analysis (e.g., RNA-Seq, DNA-Seq, methyl-Seq and ChIP-Seq), single-cell analysis, transcriptome and genome annotation, variant detection and interpretation, mass spectrometry, glycomics, and metagenomics. View a detailed list of services in iLab. Moreover, the Bioinformatics Core supports grant writing efforts by participating as key personnel, crafting support letters, and detailing analytical methodologies, thus further enabling the pursuit of groundbreaking scientific inquiries.

Bioinformatics Analysis Platforms

Our Bioinformatics Core offers access to two commercial software platforms:

Nygen – a cutting-edge platform for single-cell omics data analysis. For more details, please visit Nygen's website.

IPA – a powerful tool for pathway enrichment analysis.

To request access to Nygen or IPA, please contact us at bioinformaticscore@versiti.org or schedule now.

Publications

F Yu, S Zheng, C Yu, S Gao, Z Shen, R Nar, Z Liu, S Huang, L Wu, T Gu, Z Qian. (2025) KRAS Mutants Confer Platinum Resistance by Regulating ALKBH5 Post-translational Modifications in Lung Cancer. J Clin Invest, 135(6):e185149.

J Zhao, T Gu^#, C Gao^#, G Miao^#, H Palma-Gudiel, L Yu, J Yang, Y Wang, Y Li, J Lim, R Li, B Yao, H Wu, JA Schneider, F Grodstein, PL. De Jager, P Jin, DA Bennett. Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer’s disease neuropathology. Nature Commun 16, 2842 (2025). ^#Equal contribution. 

P Peramangalam, S Surapally, S Zheng, R Burns, N Zhu, S Rao, C Muller-Tidow, J Pulikkan. (2024) N-MYC regulates Cell Survival via eIF4G1 in inv(16) Acute Myeloid Leukemia. Science Advances, 10(9):eadh8493.