JoshuaMuia, PhD

NIGMS  1R35 GM142926 - Maximizing Investigators' Research Award (MIRA) (R35)- Investigating the regulation and substrate processing of ADAMTS13 and ADAMTS7 metalloproteases. Role: PI (2021-2026)

Constance Kwas
Senior Research Technologist

Jeremy Mattson
Senior Research Technologist

Thomas Momanyi
Graduate student

Click Here for a full list of publications from Dr. Joshua Muia, PhD

Selected Publications:

1. Barton, C., Anderson, A., Miranda., J., Terrell, D., Hovinga, J., Vesely, S., George, J., and Muia, J. Cattle-FRETS71, a Novel Fluorogenic Substrate with Broad Applicability in Characterizing ADAMTS13 Properties and Function. J Thromb Haemost. 2023; 21: 3393- 3401. doi 10.1016/j.jtha.2023.08.016
2. Mackie, I., Mancini, I., Muia, J., Kremer Hovinga, J., Nair, S., Machin, S., and Baker, R. (2020). International Council for Standardization in Haematology (ICSH) recommendations for laboratory measurement of ADAMTS13. Int J Lab Hematol. 2020:685-696.. doi: 10.1111/ijlh.13295.
3. Zwicker, J., Muia, J., Dolatshahi, L., Westfield, L., Nieters, P., Rodrigues, A., Antun, G., Metjian, A., and Sadler, J. E. Adjuvant low-dose rituximab and plasma exchange for acquired TTP, Blood 2019, in the press, https://doi.org/10.1182/blood-2018-99-113677.
4. Zhu, J., Muia, J., Deforche, L., Vanhoorelbeke, K. and Tolia, N.H., Sadler, J. E. The Hunt for the "Minimal" Structure of a Functional ADAMTS13: Study of Deletion Mutations of ADAMTS13 By Small-Angle X-Ray Scattering, Blood 2019; 133:1909-1918. PMCID: PMC6484386
5. Muia, J., Zhu, J., Garima, G., Westfield, L. A., Greco, S., Deforche, L., Vanhoorelbeke, K., and Sadler, J. E. Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation, Blood 2019; 133:1899-1908. PMCID: PMC6484387
6. Muia, J., and Catarina Casari. Reflections on scientific collaboration between basic researchers and clinicians. J Thromb Haemost 2016; 14:1905–7. (See the editorial commentary “The transcendental scientist.”)
7. Muia, J.*, Zhu, J.*, Gupta, G., Haberichter, S.L., Friedman, K.D., Feys, H., Vanhoorelbeke, K., Westfield, L.A., Roth, R., Tolia, N.H., Heuser, J.E., and J. Evan Sadler. Allosteric Activation of ADAMTS13 by Von Willebrand Factor. Proc Natl Acad Sci U S A. 2014; 111(52):18584-18589. PMCID: PMC4284596
8. Muia, J., Gao, W., Haberichter, S. L., Dolatshahi, L., Zhu, J., Westfield, L. A., Covill, S. C., Friedman, K. D., and Sadler, J. E. An Optimized Fluorogenic ADAMTS13 Assay with Increased Sensitivity for the Investigation of Patients with Thrombotic Thrombocytopenic Purpura, J Thromb Haemost, 2013; 11:1511-8. PMCID: PMC3807872