Matthew Kudek, MD
Our research focus is on T cell biology, specifically pertaining to mechanisms underlying T cell exhaustion and dysfunction. This includes a focus on tumor infiltrating lymphocytes and understanding the mechanisms leading to tumoral immune escape. We are also interested in the development of novel therapeutic approaches to reprogram dysfunctional tumor infiltrating lymphocytes towards an effector phenotype to promote tumor clearance.
- St. Baldrick's Foundation Fellowship, "Pathogen Boosted Adoptive Cell Transfer for the Treatment of Neuroblastoma," Role: PI (2021-23)
- Children's Research Institute, "Dissecting the Cellular Mechanisms of Differential Outcomes of CD20-19 CAR-T Therapy in Acute Lymphoblastic Leukemia (ALL)," Role: Co-Investigator (2020-22)
- Vince Lombardi Cancer Research Foundation, "CD19-20 CAR T Trial," Role: Co-Investigator (2020-21)
View the complete list of publications here: https://www.ncbi.nlm.nih.gov/myncbi/matthew.kudek.1/bibliography/public/
- Kudek MR, Shanley R, Zantek ND, McKenna DH, Smith AR, Miller WP. Impact of Graft-Recipient ABO Compatibility on Outcomes after Umbilical Cord Blood Transplant for Nonmalignant Disease. Biol Blood Marrow Transplant. 2016 Nov;22(11):2019-2024. PMCID: PMC5067229
- Topchyan P, Xin G, Chen Y, Zheng S, Burns R, Shen J, Kasmani MY, Kudek M, Yang N, Cui W. Harnessing the IL-21-BATF Pathway in the CD8+T Cell Anti-Tumor Response. Cancers (Basel). 2021 Mar 12;13(6):1263. PMCID: PMC7998696.
- Schauder DM, Shen J, Chen Y, Kasmani MY, Kudek MR, Burns R, Cui W. E2A-regulated epigenetic landscape promotes memory CD8 T Cell differentiation. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2013452118. PMCID: PMC8072256.