Jieqing Zhu, PhD

Jieqing  Jieqing  profile

Jieqing Zhu, PhD

Investigator

Hemostasis, Thrombosis and Vascular Biology

Associate Professor of Biochemistry 
Medical College of Wisconsin

Education and training

Doctoral Training
Institute of Microbiology, Chinese Academy of Sciences

Postdoctoral Training
Immune Disease Institute, Harvard Medical School

Contact Information
  • 414-937-3867
  • 414-937-3867
  • Thrombosis, Hemostasis and Vascular Biology

    The overall interest of our lab is the mechanism of receptor transmembrane signaling. We focus on cell surface receptors with single transmembrane domains, such as integrins, receptor tyrosine kinases, and receptor-like tyrosine phosphatases. We study how these receptors transmit signals across cell membrane through conformational regulation upon ligand binding at the extracellular domain or stimulations impinging on the cytoplasmic domain. We are using structural biology, biochemistry, and cell biology techniques to illustrate the mechanism of receptor-ligand interactions and conformational changes required for transmembrane signaling at the extracellular, transmembrane and cytoplasmic domains.

    Ongoing projects include investigating the conformational requirement for integrin bi-directional transmembrane signaling, structural and functional basis of integrin as pathogen receptors, integrin ligand interaction, and developing antibodies and small molecules targeting or stabilizing specific integrin conformation. Integrins are the important cell surface receptors that regulate cell-cell and cell-matrix interactions in development, hemostasis, antigen recognition, homing and inflammation. Integrin activation is dysregulated under pathological conditions, such as autoimmune disease and thrombosis. Our long-term goal is to understand the correlation of receptor conformational regulation and signal transduction and to help to design more efficient and safe therapeutic agents.

    1. Scientist Development Grant, American Heart Association, 2012-2016
    2. ASH Scholar Award for Junior Faculty, American Society of Hematology, 2013-2015
    3. NHLBI, R56HL122985, 2015-2016
    4. NHLBI, R01HL131386, 2016-2020

    Qifang Lao, PhD
    Visiting Scientist

    Zhengli Wang, PhD
    Research Scientist I

    Heng Zhang, PhD
    Postdoctoral Fellow

    Huong Nguyen
    Postdoctoral Fellow

    Kim Hung Huynh
    Postdoctoral Fellow

    Abigail Watson
    Assistant Research Technologist

    Former Lab Members:

    An Li, PhD
    Postdoctoral Fellow (2019-2021)

    Dongwen Zhou, PhD
    Research Scientist I (2014-2018)

    Julia Williams 
    Undergraduate Student (MCW SPUR)

    Aye Myat Myat Thinn, PhD
    Predoctoral Fellow (MCW IDP) (2014-2018)

    Megan Wetzell
    Undergraduate Student (2018)

    Magen Gates
    Summer Student (MCW ROAD) (2017)

    Yan Zhao, MD
    Postdoctoral Fellow (2015-2016)

    Xiulei Cai, PhD
    Predoctoral Fellow (2014-2015)

    Jiafu Liu, PhD
    Postdoctoral Fellow (2011-2014)

    Can Zhang, PhD
    Postdoctoral Fellow (2013)

    Chuanmei Zhang, PhD
    Predoctoral Fellow (2013)

    Linzheng Shi
    Summer Student (2013)

    Nada Haydar, BS
    Graduate Student (2012)

     
    Thrombosis & Hemostasis
    We study the properties of blood that cause it to clot. Our findings help to treat diseases that cause blood clots or excessive bleeding.
     
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