Hartmut Weiler, PhD

Hartmut  Hartmut  profile

Hartmut Weiler, PhD

Ziegler Family Chair for Research, Senior Investigator

Hemostasis, Thrombosis and Vascular Biology

Ziegler Family Chair for Research
Senior Investigator

Blood Research Institute, Versiti

Associate Professor
Department of Physiology
Medical College of Wisconsin

Director
Transgenic Core
Medical College of Wisconsin

Education and training

Postdoctoral Fellow
Department of Biology, Massachusetts Institute of Technology

Dr.rer.nat. (PhD) 
Biology/Biochemistry, Technische Hochschule Darmstadt

Diplom Biologe (MS)
Technische Hochschule Darmstadt, Germany

Contact Information
  • 414-937-3813
  • 414-937-3813
  • Thrombosis, Hemostasis, Vascular Biology / Immunobiology

    Our focus is understanding the role of the blood coagulation system in general, and the biological functions of the natural Thrombomodulin (Thbd) – protein C anticoagulant pathway, in particular. Current projects investigate the cellular and molecular mechanisms by which these physiological mechanisms affect the host response to bacterial infections, control the development of the placenta, regulate the activation of the blood coagulation system, and affect recovery of the hematopoietic system from injury and stress. Insights into the physiological functions of the protein C system in these contexts are used to explore the potential for therapeutic interventions targeting this pathway in diseases like severe sepsis, malaria, bone marrow failure after exposure to lethal doses of radiation, and in other progenitor cell-driven processes of tissue remodeling after injury.

    In collaborative studies with Investigators at MCW and the Blood Research Institute, we investigate the function of a protein (Gmap5) that has been linked to the development of autoimmune type 1 diabetes. We found in mouse models that this protein has a critical role in hematopoiesis and cell survival. Current research aims at delineating the biological mechanisms regulated by Gimap5 during hematopoiesis, and understanding how a defect in this gene might be causing autoimmune disease.

    Dr. Weiler directs the joint Transgenic Core Facility of the Medical College of Wisconsin (MCW) and the Blood Research Institute / Blood Center of Wisconsin. The facility provides a wide range of services facilitating the generation, maintenance, and acquisition of genetically altered mice and rats.

    • R01 HL133348, Regulation of Innate Immunology by Coagulation Receptors (07/01/2016 - 04/30/2020)
    • P01 HL044612, Core C, Molecular and Cellular Mechanisms in Transfusion Medicine (12/01/2010 - 11/30/2015)
    • R01 HL130678, Discovery of novel vascular therapies targeting PfEMP1-mediated cytoadhesion in severe malaria (09/15/2015 - 05/31/2019
    • R01 HL117132, Protein C pathway function in Hematopoiesis (04/09/2014 - 03/31/2018)
    • Pilot Grant, Clinical and Translational Science Institute of Southeast Wisconsin (04/01/2015 - 03/31/2016)

    Jamie Foeckler 
    Senior Research Technologist

     Irene Hernandez
    Senior Research Technologist

    Jennifer May
    Animal Technician

    Yamini Ogoti
    Research Technologist 

    Mark Zogg
    Research Technologist

    Shawn Kalloway
    Research Technologist

    Complete List of Publications in MyNCBI Bibliography
     

    Selected Publications

     
    Thrombosis & Hemostasis
    We study the properties of blood that cause it to clot. Our findings help to treat diseases that cause blood clots or excessive bleeding.
     
    Join Versiti Blood Research Institute
    Versiti Blood Research Institute, located in Milwaukee, Wisconsin, includes basic and clinical researchers in a variety of blood health fields.
     
    Our Experts
    Research investigators, postdoctoral fellows and laboratory staff at Versiti Blood Research Institute and Diagnostic Laboratories.
     
    Versiti Blood Research Institute
    Versiti Blood Research Institute investigators study blood disorders like hemophilia, blood cancers like leukemia, and other blood diseases.